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Can online review of biological research improve to the point that it supersedes the current journal based evaluation system? Perhaps. But it will require a commitment on the part of the scientific community to devote the time and courtesy now accorded formal peer review to open online assessment of manuscripts that have not been subjected to any preselection criteria. In the meantime, we recognize online commentary for what it does provide: fresh voices whose insights will help improve the iterative processes of science and peer review. The saposins (saposin A to saposin D) are small, non enzymatic proteins that localize to lysosomes and facilitate the hydrolysis of different glycosphingolipids in these compartments. For example, saposin B 'activates' the degradation of sulphatide by arylsulphatase A, Nike Air Jordan Mens

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and saposin C promotes the degradation of glucosylceramide by glucosylceramide glucosidase. Consequently, .

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ensure that no image manipulation exists. The process ultimately subjects a published manuscript to varying degrees of scrutiny by about ten individuals. Can this elaborate process of peer review nevertheless miss fatal flaws in a paper or, conversely, overlook the importance of a new discovery? It can. And the blogosphere can inform us of such instances. Yet we believe that the multiple stages of independent evaluation of a manuscript minimize these occurrences, and the majority of comments from external referees reflect a careful and detailed analysis of the data and their Nike Air Jordan Red And White interpretation.

field, evaluate their comments and concerns and draft a final decision in consultation with the other editors.

The majority of manuscripts that we publish are subjected to at least two rounds of peer review. Our production editor carries out a final check on figures slated for publication to Air Jordan Red Black White

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´╗┐al board. Because professional editors have no research commitments or agenda, we feel that the absence of an editorial board minimizes the possibility of any external bias in the initial decisions that we make. Instead, submissions are allocated to six manuscript editors according to subject areas, broadly defined as cancer, neuroscience, physiology, cardiovascular, basic and applied immunology and infectious disease. Each editor is charged with assessing his or her assigned manuscripts in their entirety and in terms of the conceptual novelty, advance, strength of the findings and the degree to which the work fits the purview of the journal is, demonstrating new insight into the mechanisms of human disease or its therapy. These meetings are lengthy, can be highly contentious at times and are a continual test of our own skills of critical analysis as well as the papers we discuss. In this manner, a decision on each manuscript is not meted out by a single editor, but instead is based on the combined input of the six manuscript editors and our chief editor. For manuscripts that are externally reviewed primary research papers, as well as Reviews, Commentaries, Perspectives and most Correspondences editors select appropriate experts in the Nike Air Jordan Retro 12

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