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Robert Klein. Although officially retired from CIRM he chaired the board from 2004 to 2011 (see 'State of funding') Klein's office is adorned with mementos of the agency: a commemorative shovel from the groundbreaking of a CIRM funded stem cell research centre, and a photo of him with former governor Arnold Schwarzenegger at the ribbon cutting ceremony. It was Klein's idea to ask voters to support stem cell research in 2004, through a ballot measure called Proposition 71. When he succeeded, CIRM instilled a kind of euphoria in stem cell scientists, who were Air Jordan Red Velvet 12 at the time still reeling from a 2001 decree by then President George W.

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Bush that severely limited federal funding for embryonic stem cell research. California's commitment removed this roadblock and revealed that many in the state and the country supported the research. "Before CIRM, the conversation was about where to draw restrictions on embryonic stem cell research," says Sean Morrison, a stem cell and cancer biologist at the University of Texas Southwestern in Dallas. "Once Air Jordan 11

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´╗┐ects to the patient as soon as possible," he says. Californians voted CIRM into existence in 2004, making it the largest funder of stem cell work in the world. The money the proceeds of bond sales that must be repaid with $3 billion in interest by taxpayers helped to bring 130 scientists to the state, and created several thousand jobs there. It has funded research that led to the publication of more than 1,700 papers, and it has contributed to five Air Jordan 5

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President Barack Obama might have loosened the restrictions on federal funding for embryonic stem cell research in 2009, but some presi.

the California voters supported CIRM, the conversation shifted to how the rest of the country could keep up. " Indeed, five other states went on to set up stem cell research agencies. Planning the sequelOne afternoon, Klein doodles on a legal pad as he lays out the case for 'CIRM 2'. He writes the word 'scientists', then draws a box around it. Science, he says, is more under attack than ever before.

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Its backers have begun to chart a course for once again reaching out to voters, this time for $5 billion (with another $5 billion in interest) in 2016. And it is under intense pressure to produce results that truly matter to the public. Whether or not CIRM succeeds, it will serve as a test bed for innovative approaches to funding. It could be a model for moving technologies to patients when conventional funding sources are not interested. Much of what is celebrated and lamented about CIRM can be traced back to the Palo Alto real estate developer who conceived of it: Nike Air Jordan Retro 12 Black

early clinical trials. The institute has navigated a difficult path, however. CIRM had to revamp its structure and practices in response to complaints about inefficiency and potential conflicts of interest. It has also had to adapt its mission to seismic shifts in stem cell science. Now, ten years after taking off, the agency is fighting for its future. It has a new president, businessman Randal Mills, who replaces biologist Alan Trounson.

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